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In pathological conditions such as cancer, dysregulation of these mechanisms leads to vascular hyper-permeability that in turn may exert direct effects on the tumor microenvironment including increased interstitial pressure and impaired therapeutic delivery [127]

PDK1-deficient erythrocytes exhibit a reduced cytosolic Ca 2+ concentration and eryptosis upon exposure to cellular stressors [153]

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Most importantly, be patient as your transformation takes time