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Zimmerman, A

That is a problem for several reasons: GLP-1 medications carry boxed warnings about thyroid C-cell tumors in rodents and are contraindicated in people with a personal or family history of medullary thyroid carcinoma or MEN2

Moreover, evidence has shown that during the DNA damage response, normal cells show a decrease in glutaminolysis controlled by SIRT4 protein suppressing GLUD1

Interestingly, treatment of these mice with trabectidin resulted in adipocytic differentiation, which was increased by concurrent treatment with the peroxisome proliferator-activated receptor (PPAR) agonist rosiglitazone

Key Takeaways GLP-1 drugs mimic a hormone your body already makes to suppress appetite and regulate blood sugar