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PMID 25204972 Systemic TB-4 failure in pigs - IV systemic TB-4 did not produce cardioprotection in a pig model

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For example, doxorubicin (DOX) has cardiac side effects that lead to irreversible dilated cardiomyopathy and congestive heart failure, and acetylcarnitine has been shown to prevent cardiac functional and structural damage caused by DOX-induced oxidative stress [289]

This is why many researchers recommend its use to enhance weight loss when combined with a calorie-restricted diet and physical activity