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That law requires that new legislation not increase the deficit over 5- and 10-year windows, or else automatic cuts (sequestration) are applied to certain mandatory programs

Clinical trials in Alzheimers disease Alzheimers disease is where the 2025 data forced the largest revision, and where the contrast between observational promise and trial outcome is sharpest

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10.1101/gad.13.1.76 64 JaganjacM.MilkovicL.ZarkovicN.ZarkovicK