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The SURMOUNT program is composed of multicenter double-blind RCT evaluating the efficacy and safety of OW tirzepatide compared to placebo on top of dietary and physical activity recommendations in patients with obesity or BMI 27 kg/m 2 with 1 weight-related complication 9

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Additionally, hyperthyroidism was shown to increase protein catabolism leading to faster elimination of modified proteins, including carbonylated ones [46]

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The findings implicate DA in the aversive experience of acute opioid withdrawal and in the concomitant activation of the HPA axis