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IGF-1 acts mostly as an endocrine hormone secreted primarily by the liver [2,3] and transported to the target tissues

Critical Role of TLR4 on the microglia activation induced by maternal LPS exposure leading to ASD-like behavior of offspring

tefani M, Toki S (2020) Serum 25-hydoxyvitamin D concentrations in relation to Hashimotos thyroiditis: a systematic review, meta-analysis and meta-regression of observational studies

Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

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