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Increases insulin production, a hormone that lowers the blood sugar level while inhibiting glucagon secretion, which is a hormone that raises blood sugar, and reduces appetite and energy intake while delaying gastric emptying.s

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In the highest dose arms, approximately 6070% of participants experienced at least one GI adverse event at some point during titration

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However, despite their notable efficacy, gastrointestinal side effects remain a significant limitation in their clinical use