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Pharmaceutical-grade API for some of these peptides do not yet exist at commercial scale, in large part because these substances have not been authorized for human use

PE-22-28: TREK-1 Channel Blockade# PE-22-28 (Gly-Val-Ser-Trp-Gly-Leu-Arg) is a synthetic 7-amino acid peptide derived from spadin, itself an endogenous peptide released by proteolytic processing of sortilin (neurotensin receptor-3)

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IL1RAPCD3 plasma pharmacokinetic parameters (Cmax, T1/2, and AUC) were derived from the mouse concentration-versus-time data using noncompartmental analysis methods in WinNonlin, software v8.6 (Certara)