[6] [3] [10] A mild deficiency may not cause any discernible symptoms, but moderate deficiency can cause various symptoms, such as feeling tired, lightheadedness, headaches, cold intolerance, pale skin, sore tongue, upset stomach, loss of appetite, hair and skin color changes, numbness or tingling (pins and needles) of the fingers and toes, and tinnitus, and vision, cognitive or psychological problems
This is because an intramuscular injection allows you to bypass the digestive system so stomach absorption is not an issue
It encodes MOTS-c, a 16-amino-acid peptide that travels from the mitochondrial matrix into the nucleus and even into the bloodstream, acting less like a local signaling molecule and more like a systemic hormone
The solvent depends on the peptide and its solubility profile
If fatigue persists or worsens over time, checking B12 levels, thyroid function, and other nutritional markers is warranted