Missing multiple doses in a row or extending the interval beyond 8 to 10 days can result in noticeable appetite return, increased food cravings, and slower metabolic activity
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Levy G, Tang MX, Cote LJ, Louis ED, Alfaro B, Mejia H, et al
Developmental and tissue-specific regulation of proglucagon gene expression
They are not recommended during pregnancy or breastfeeding, and women of childbearing potential should use effective contraception