The GPX family contains eight members (GPX1-GPX8), of which GPX1-GPX4 and GPX6 (human) members have an active center of selenocysteine, which is an important selenoprotein in mammals (Table 1)
Interestingly, differences in prooxidative parameters were more profound in acute coronary syndrome patients compared with coronary artery disease patients indicating that the acute form of coronary artery disease is more susceptible to oxidative damage, suggesting that use of antioxidant therapy may be warranted to reduce oxidative stress in this disorder (154)
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GHK-Cu acts as a powerful antioxidant, neutralizing free radicals and protecting cells from oxidative stress
202,203,204 AXIN is a scaffold protein of the degradation complex, and mutation of AXIN1/2 substantially affects Wnt signal transduction activity
