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Unlike cysteine (which is unstable and poorly absorbed), NAC is stable, well-absorbed, and rapidly increases intracellular glutathione
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However, chronic stimulation of these paracrine myofibroblast pathways in IBD raises theoretical safety concerns regarding stricturing, fibrosis risk, and the necessity for rigorous dysplasia surveillance, which remain critical hurdles for long-term clinical development
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(2021) Characterization and quantification of selenoprotein P: Challenges to mass spectrometry, Int
10.1016/j.toxlet.2013.10.023 Toxicol
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