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The result is that more of the peptide is available for binding to important receptors and thus IGF-1 DES is more potent (same effects at lower doses) than IGF-1 itself

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For instance, systems like solid lipid nanoparticles and self-emulsifying drug delivery systems can overcome gastrointestinal biochemical barriers by utilizing lipid matrices to solubilize and tightly encapsulate hydrophobic drugs, while simultaneously stimulating intestinal lymphatic transport to bypass hepatic first-pass metabolism

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Many pre-mixed blends include both peptides for this reason