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Whitehead et al., 2001), as well as mitochondrial dysfunction (Lee et al., 2003), alterations of brain mitochondria (Gluck and Zeevalk, 2004) and dysfunction in Complex I activity (Jana et al., 2007, 2011

It was recently reported that CVD patients have two-fold higher plasma TMA concentrations than healthy individuals, indicating that TMA may also contribute to the pathogenesis of CVDs

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