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Sirtuin modulation Modulating sirtuin activity by targeting NAD + -dependent deacylation may hold therapeutic potential for impacting mitochondrial homeostasis and other cellular pathways related to aging and disease

Nervous system: IGF-1 has neuroprotective properties and supports cognitive function

The insulinogenic index, a measure of how much insulin the body needs to maintain glucose control, dropped significantly

PMID: 21859473

The limited success of anti-angiogenic therapy in glioma is likely at least in part due to an escape from therapy by invasive tumor cells co-opting the vasculature of the surrounding brain tissue