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Coordinated upregulation of a series of endogenous antioxidants and phase 2 enzymes as a novel strategy for protecting renal tubular cells from oxidative and electrophilic stress

doi:10.1186/s12872-023-03228-5 Marso SP, Daniels GH, Brown-Frandsen K, et al

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Some, like Leptin, introduced in 1999, managed to produce limited weight loss without severe side effects but not enough to be worthwhile