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Ageing of the brain is paralleled by an increase of the glutamate to glutamine ratio indicating abnormal operation of the glutamate (GABA)-glutamine shuttle

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Moreover, in both young and aged diabetic mice subjected to MCAO, exendin-4 treatment was shown to significantly polarize microglia/macrophages towards an anti-inflammatory M2 phenotype in the injured hemisphere compared to the non-injured hemisphere [76]

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