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214,215 A systematic review of 12 clinical trials found that CoQ10 supplementation in patients with CKD significantly reduced blood levels of malonaldehyde, a marker of oxidative stress, and high-sensitivity C-reactive protein (hs-CRP), which is a marker of systemic inflammation

Gene, transport orientation and the clinical drug substrates of each transporter is included (Polli et al

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The underlying reasons for these discrepancies in findings are currently unclear, indicating the potential involvement of additional mechanisms that may influence the effects of estrogen on Klotho proteins