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For the higher-dose Wegovy HD (7.2 mg), the STEP UP trial showed an average of 18.7% weight loss at 72 weeks, compared to 3.9% with placebo

This article reviews the current evidence on how semaglutide interacts with stress hormone pathways and metabolic health

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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations GCs, glucocorticosteroids