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M., Bijelic, V., Barrowman, N., Sicard, V.,

Compounded versions introduce additional variables

Baseline assessment helps determine if lifestyle-first strategies are sufficient or if additional support is warranted

For example, most polyphenols l-based nano-formulations are reported at the proof-of-concept or rodent-model stage, with little evidence of scalable manufacturing processes, long-term safety studies, or stability data under ICH guidelines