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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

At low Cd concentrations, citric acid is a significant ligand and contributes to the accumulation and tolerance of Zn (Najeeb et al., 2011)

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