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According to FDA labeling, exenatide is not recommended in patients with estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m

*Ozempic has not been studied specifically as a weight-loss medication

In June 2023, Lilly reported that Orforglipron led to an average weight loss of up to 14.7% over 36 weeks in adults with obesity or overweight based on Phase II trial results

Most studies will tell you this effect is probably in the neighborhood of an extra 150-200 calories of excess energy expenditure per day

Vagotomy in animal studies is said to disrupt the transfer of -synuclein derived from the gut to the CNS, but human observational evidence is inconsistent, with some studies indicating no change in PD incidence and others suggesting a reduced risk following truncal vagotomy (Elfil et al., 2020)