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Astrocytes induce apoptosis by secreting TNF-, IL-1, and excess Glu, which activate neuronal TNFR1 or cause Ca 2+ overload, triggering extrinsic (caspase-8/-3) and intrinsic (Cyt C release) apoptosis [251]

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Genetic variation in the GLP1R gene (rs6923761), GIPR receptor pathway (rs1800437), and appetite-regulation genes like FTO (rs9939609) and MC4R (rs17782313) influence individual response rates and side effect tolerance

While this is a promising area of study, it is important to note that semaglutide is not currently approved for RA