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Pan and colleagues have reported that melatonin influences Schwann cell proliferation and migration via the SHH signalling pathway after peripheral nerve injury, as they have observed an increased expression of SHH and the gliomaassociated oncogene Gli1 in RSC96 Schwann cells following an in vitro melatonin treatment (Wagstaff et al., 2020)

In vitro mutagenicity tests Test Organism Metabolic Dose range Mutagenic Reference activation (+ or -) potential Prokaryotes Point mutation Salmonella typhimurium + and - 0.33-6.6 g/plate negative Banzer (1977a) (5 strains) Point mutation S

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