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For weight management, NICE recommends liraglutide 3mg (Saxenda) or semaglutide 2.4mg (Wegovy) for adults with a BMI of at least 35 kg/m (or 30 kg/m with weight-related comorbidities) alongside a reduced-calorie diet and increased physical activity

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In March 2026, the FDA issued warning letters to 30 telehealth companies for making false or misleading claims about compounded GLP-1 products, signaling aggressive regulatory enforcement

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The approval gives Novo Nordisk an advantage over its US rival Eli Lilly, which is developing its own oral pill against obesity and diabetes, based on orforglipron and expected on the US market no earlier than March 2026 , but still awaiting the Fda green light