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Effects of GSTM2 on LD content do not absolutely depend on regulating ROS level Because GSTM2 has antioxidant activity (as described in the Introduction), the potential effect of ROS on cellular lipid formation should be examined

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The increase in PKA activity also leads to closure of ATP-sensitive potassium channels, which in turn causes depolarisation of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of secretory granules and thus secretion of insulin

Graphical Abstract Graphical abstract: Bispecific domain antibody BiSpekDAb

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