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Among cases of severe hepatotoxicity occurring during VPA therapy, survival has been reported mainly in those patients treated with carnitine [6467], and this approach is likely to be biased

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In agreement with our results, earlier studies have demonstrated that the upregulation of carbohydrate metabolism associated genes, including SPS, SuSy, VI, and NI, leads to increased accumulation of glucose, fructose, and sucrose under cadmium stress in wheat [61] and chilling stress in peach [91]

Before commencing the experiment, mice should be housed individually for a week to adapt to their environment

Then, the well plates were washed with 1 ml of 0.9% NaCl, and the cells were lysed with 1 ml of chloroform:MeOH:H 2 O (1:3:1) and centrifuged at 15,000 g for 5 min at 4 C