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4.2.2 Resveratrol and curcumin nano-systems Natural compounds such as resveratrol and curcumin have long been recognized for their antioxidant and immunomodulatory effects, yet their therapeutic use is hindered by poor solubility, instability, and low bioavailability [50, 123]

[4] [5] Some patients report temporary digestive changes following injections, though the exact mechanism for this is not well established

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