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Preclinical studies suggest GLP-1 agonists may reduce synovial macrophage infiltration and decrease production of matrix metalloproteinasesenzymes responsible for cartilage degradation in RA

The diversity in metabolites explains the mechanisms of inflammatory cell infiltration, cytokines accumulation, angiogenesis, bone destruction, and muscle atrophy

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Tesamorelins half-life is only 26-38 minutes, yet it produces sustained effects because the growth hormone it stimulates has downstream effects through IGF-1 that last much longer