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It is also called dermographia, dermatographic urticaria, or skin writing, and tends to get lumped into atopic dermatitis diagnosis.[ref] Cold urticaria (hives or welts due to cold) or cold-dependent dermatographism, another mast cell-related condition, happens when the skin is lightly scratched after being chilled.[ref] Peripheral neuropathy and mast cell activation: Neuropathy causes numbness, pain, pins and needles, and weakness, usually in the hands and feet

Additionally, morning dosing may provide coverage during daytime meals when carbohydrate intake is typically higher

Therefore, one of the most important approaches in melasma management and potentially mitigating its progression is photoprotection

LHP, lipid hydroperoxide