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CJC-1295 (no DAC) binds GHRH receptors on pituitary somatotrophs, initiating GH secretion through the cAMP/PKA signaling cascade 2

Clinical Trial Findings: CJC-1295 (with DAC version) progressed to Phase 2 trials for growth hormone deficiency but was discontinued (due to an adverse event later deemed unrelated to the drug)

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Tesamorelin (Egrifta) is the one FDA-approved GHRH analog, approved November 2010 for HIV-associated lipodystrophy based on Phase 3 trials in 816 patients