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139 In vivo studies have demonstrated nasal application of N-acetylcysteine in rats can reduce goblet cell loss and inflammation as well as promote wound healing of nasal mucosa, 140 and combination of N-acetylcysteine and non-ionic surfactant (polyoxyethylene (C25) lauryl ether) can improve nasal bioavailability as a result of mucolytic activity of N-acetylcysteine in decreasing mucus viscosity

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