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Common changes include facial volume loss, skin laxity, dryness, and injection site reactions

Concurrently, pivotal metabolic enzymes within the amino acid synthesis pathway, including glutamate-oxaloacetate transaminase 1 (GOT1), glutamate-pyruvate transaminase 2 (GPT2), pyrrolidine-5-carboxylic acid reductase 1 (PYCR1), and phosphoserine aminotransferase 1 (PSAT1), demonstrated increased expression [214]

These effects occur because GLP-1 receptor agonists fundamentally alter digestive processes, particularly gastric emptying rates