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This mechanism means orlistat is a non-systemic medication

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This understanding is in line with the chronotropic effects of GLP-1 RA treatment, which in a large meta-analysis was shown to be associated with heart rate increases of up to 3.35 beats/min (Sun et al., 2015)

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Acknowledgements We thank OPEN Health Communications for their editorial and graphics support, as well as coordination during the manuscript development, which was funded by Novo Nordisk A/S