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CRISPR/Cas9, a New Approach to Successful Knockdown of ABCB1/P-Glycoprotein and Reversal of Chemosensitivity in Human Epithelial Ovarian Cancer Cell Line

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This suggests that knocking out CUL5 in human CD8 + CAR T cells similarly enhances CAR signaling activity, IFN- secretion, and tumor cell clearance capability ( + CAR T cells similarly enhances CAR signaling activity, IFN- secretion, and tumor cell clearance capability