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2,3 Mechanistic explanations for the development of CI secondary to constipation include reduced efferent vagal cholinergic activity resulting in reduced colonic blood flow, as well as increased intracolonic luminal pressure resulting in reduced colonic blood flow with mucosal-to-serosal shunting of blood

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It was found a significant decrease in lymphohistiocytic infiltration in the gastric mucosa, restoration of the structure of the pancreas, and increased focal proliferation of the glandular epithelium which were considered as the signs of morphological restoration of the epithelium and reduction of the signs of its dysplasia

Some individuals may experience mild redness or slight discomfort at the injection site, but these effects are usually temporary

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