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Most of the compounds synthesized using substrate-based inhibitors approach, these compounds are proline mimetic, which occupy S 1 -pocket, P 2 -substituent of drug occupies S 2 -pocket whereas P 1 -substituent occupies S 1 -pocket of DPP-4 protease, and their basic structure interacts via either forming a covalent or non-covalent bond [36]

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