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Reply More than 67 million people rely on Medicarebut many still face barriers to the care they need
Despite varied management strategies, the overall acute mortality rate is substantial
13 In the SURPASS-4 trial (phase III), participants taking tirzepatide showed a much lower occurrence of composite kidney endpoint (time to first occurrence of eGFR decline of at least 40% from baseline, end-stage kidney disease, death due to kidney failure, or new onset albuminuria) compared with those who received insulin glargine (HR 0.58)
These side effects occur in approximately 10-40% of patients depending on the specific medication and dose, typically appearing during dose initiation or escalation
Moreover, in the FLIRT trial, 63 patients with biopsy-proven NASH and increased ALT, of whom 20 were diabetic, were randomized to receive either rosiglitazone or placebo for 1 year
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