Mercury accumulates in each fish from everything it eats and is not excreted, so it concentrates further with each step up the food chain
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While the primate studies found no evidence of ectopic fat accumulation in the liver or arterial walls, the concern remains valid for larger-scale or longer-duration use
For some individuals, these jumps in dosage can be too aggressive, leading to significant gastrointestinal side effects
The inhaled silica particles can be directly phagocytosed by alveolar macrophages (AMs), and thereby triggers NLRP3 inflammasome activation and IL-1 production, which results in a cascade release of proinflammatory and profibrotic cytokines, i.e., IL-6, tumor necrosis factor (TNF-) and TGF-1