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For FDA timeline details, see our FDA approval status article

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Pilz, S., Frisch, S., Koertke, H., Kuhn, J., Dreier, J., Obermayer-Pietsch, B., Wehr, E., & Zittermann, A

[4] These mostly disappointing results havent stopped food companies and supplement sellers from banking on antioxidants

Interestingly, it was shown that such production was enhanced in CD56 + CD16 - NK cells isolated from squamous cell carcinoma patients and was TGF--dependent (111)