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Absorption is more fragile than injections, so timing and consistency matter more with daily oral dosing

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Tirzepatide comes in pre-filled injection pens with weekly dosing at 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, and 15mg strengths, with established dosing protocols from extensive Phase 3 trials

12 , in a similar WL intervention, reported no changes in subjective feelings of appetite and a significant decrease in basal active GLP-1, but different from our study a significant decrease in basal PYY and CCK, and a significant decrease in postprandial concentration of PYY at week 9 under ketosis