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Our proposal would help mitigate the risk of paying substantial shared savings to an ACO where the savings are attributable to the variability in benchmark calculations rather than actual program performance as can be the case for ACOs with fewer than 5,000 assigned beneficiaries in one or both of benchmark years 1 and 2 that are susceptible to performance variability

Higher glutathione levels influence red blood cell count, hematocrit, and hemoglobin

34 It is important to note that the antioxidant properties of Mn are outcompeted by cellular iron binding to MnSOD, so iron may counteract the benefits of manganese antioxidants

In some cells, however, selenium restriction reduces GPx-1 activity and protein to nearly undetectable levels with modest or no change in transcript levels (20, 56), suggesting that nonsense-mediated decay does not mediate suppression of GPx-1 protein expression under conditions of selenium restriction in all cells

An in-depth understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity