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Gastrointestinal effects are the most common

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The 72-hour minimum is not arbitrary

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Annu Rev Biochem

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High Expression of Bovine Alpha Glutathione S-Transferase (GSTA1, GSTA2) Subunits Is Mainly Associated with Steroidogenically Active Cells and Regulated by Gonadotropins in Bovine Ovarian Follicles

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In cell models, activation of MC1R by MT-II leads to stimulation of the cAMP/PKA pathway and an increase in eumelanin synthesis

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