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GLP-1 receptors are found in key brain regions, such as the ventral tegmental area and the nucleus accumbens, which are central to the mesolimbic dopamine system

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The landmark SURMOUNT5 trial (NCT05822830) randomised 751 adults with obesity (without diabetes) to either the maximum tolerated dose of tirzepatide (10 mg or 15 mg) or semaglutide (1.7 mg or 2.4 mg)

People on ACE inhibitors, ARBs, beta blockers, or calcium channel blockers may need dose reductions over time to avoid hypotension