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Patients with mild to moderate renal impairment generally do not require dose adjustment, but closer monitoring may be warranted, particularly for signs of gastrointestinal adverse effects that could lead to dehydration and worsening renal function

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At baseline, mean age was 46 years (range 18-86), 74% were female, 75% were White, 13% were Asian and 6% were Black or African American

These may include: Nausea

A patient who maintains healthy eating patterns, exercises regularly, and manages stress may sustain results on a lower dose than someone facing ongoing dietary temptations or high stress