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Weight changes Weight effects are the slowest and least predictable

Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls

In obesity, NNMT activity is unusually high in fat cells, which means a lot of nicotinamide gets thrown out before it can be turned into NAD+

However, certain groups require particular attention: Vegans and strict vegetarians must obtain B12 through: Fortified foods (plant-based milk alternatives, breakfast cereals, nutritional yeast) Regular B12 supplementation (typically 1025 micrograms daily or 2000 micrograms weekly) The Vegan Society recommends that all vegans supplement B12, as plant-based sources are unreliable and insufficient

Avoid rubbing or touching the area unless you are gently massaging it to alleviate discomfort