While it often leads to significant weight loss, its use solely for weight management is considered off-label. For men (and women) specifically seeking FDA-approved medication for chronic weight management, Wegovy (also semaglutide) or Zepbound (tirzepatide) are the approved options, generally prescribed at higher doses than Ozempic
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GLP-1 medications have changed the game for weight loss, but not everyone sees the same results
It was proposed that there were two genetic alleles that gave rise to three major phenotypes in man referred to as Hp1-1, Hp2-1, and Hp2-2
Since natural GLP-1 is rapidly deactivated by an enzyme in our blood, by the time GLP-1 is secreted by our gut, makes it through our liver, heart, and lungs, then out into our arteries, only to later reach the veins where the lab tech is pulling out blood, the levels we see are lower than the arterial levels that GLP-1 receptors are exposed to throughout our body, though only by a relatively small amount