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These systems operate synergistically rather than in isolation, collectively maintaining female reproductive homeostasis through three principal mechanisms ( Figure 1 )

Diabetologia 44 , 129146 (2001)

The mechanism and result are similar to that of GSTP and JNK, in that GSTM1 sequesters ASK1 through complex formation and prevents its induction of the pro-apoptotic p38 and JNK portions of the MAPK signaling cascade

A 2024 retrospective study published in the Annals of Dermatology found that women and older adults are particularly susceptible to weight-loss-induced telogen effluvium, even when the degree of weight loss is not more severe than in other groups

J Anim Ecol