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N = 3 independently prepared samples examined over 3 independent measurements

Several critical questions remain unresolved: (1) most existing studies are confined to animal and cellular models, with a notable lack of large-scale population-based investigations and clinical validation, thereby impeding translational application

121 Treatment of mice with a combination of rifampicin and isoniazid caused ROS formation and LPO in hepatocytes, a reduction of GPx4, and an increase in acyl-CoA synthetase long-chain family member 4 (ACSL4)

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First, it directly neutralises reactive oxygen species the unstable molecules that cause oxidative stress and damage cellular structures over time