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The PAR2-K36E [ B6N(Cg)-F2rl1 em1Wmrf /Tarc ] was generated by pronuclear injection and CRISPR-mediated targeting to change the F2rl1 coding sequence from 5-AGTAAAGGAAGAAGT-3 (S K G R S) to 5-AGTgAAGGAcGAtcg-3 (S E G R S), which also introduced the diagnostic silent PvuI restriction site

More recently, Lilly reported topline phase 3 TRIUMPH-1 results in adults with obesity or overweight without diabetes

Biochem Biophys Res Commun 145 : 888894

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